I'd stick with a more flexible solution that isn't locked to a specific vendor.

We've had customers migrating from Nutanix, because renewal cost was huge. They have different hardware options, but we worked with their Supermicro boxes. One of the options was VMware vSAN, which works pretty good from my experience.

I would agree about vendor lock. We had a great experience with Starwinds Appliances. They are more flexible and cheaper.

As mentioned, Nutanix is KVM under the hood, so you can easily migrate to any KVM-based solution. I tried migrating to oVirt and Proxmox.

Not to say that HCI doesn't have a place, but unless you have a 100% firm grasp of what you will be doing in five years, I'd stick with a more flexible solution that isn't locked to a specific vendor.

In reality, it's not that difficult to migrate from AHV to say oVirt, ProxMox or any other "KVM under the hood" virtualization platform.

Nutanix AHV is just KVM/QEMU. To date, we haven't encountered an OHV or pre-made VM that couldn't be run in production under KVM/QEMU, even VHDX appliances from Microsoft. However, we do happen to maintain a large operational knowledge of KVM/QEMU that you can't expect to find at a Nutanix customer.